Accelerated Ovarian Failure: A novel, chemically induced animal model of menopause
نویسندگان
چکیده
منابع مشابه
Ovarian neoplasm development by 7,12-dimethylbenz[a]anthracene (DMBA) in a chemically-induced rat model of ovarian failure.
OBJECTIVES The objectives were to determine the time course for ovarian failure in rats caused by 4-vinylcyclohexene diepoxide (VCD) and develop a model for ovarian cancer in which ovarian neoplasms were chemically induced in an animal that was follicle depleted, but retained residual ovarian tissue. METHODS Initially, female Fisher 344 rats were treated with VCD (to induce ovarian failure) o...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2011
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2010.12.064